The abstract is read at the publisher; the summary is JClub's.
In primary CD4+ T cells from people living with HIV-1 on ART, HIV-1–infected and uninfected cells are lysed at identical rates under CTL-engaging single-chain diabodies, with no general resistance.
- Why it matters: Shock-and-Kill cure strategies depend on CTL-mediated killing, but selective pressure could enrich for reservoir cells with altered death pathways or other killing-resistant features.
- What they did: The study measured lysis rates of uninfected and HIV-1–infected primary CD4+ T cells from PLWH under identical CTL pressure using CTL-engaging single-chain diabodies in latent and active infection, including targeting via HLA-E.
- The result: The apparent survival advantage for actively infected cells reflects reduced surface antigen availability from Nef-dependent MHC class I downregulation, and no survival advantage occurs when CTL triggering is directed through HLA-E.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.