extracellular ATP: an emerging primer for plant stress memory.

Extracellular ATP (eATP) is proposed as an integrative priming hub in plants, linking purinoceptor 2K1/2 (P2K1/2) signaling to Ca2+ and reactive oxygen species pathways.

• Why it matters: Prior stress exposure can create durable plant memory, but the immediate signals that set the primed state are not well defined.
• What they did: The authors synthesize a framework in which eATP, released after cellular perturbation, activates P2K1/2 and coordinates downstream signaling with phytohormones, energy sensing, chromatin regulation, and noncoding RNAs.
• The result: The framework separates established signaling from hypothesized epigenetic memory and suggests a guide for designing plant resilience strategies.

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