The abstract is read at the publisher; the summary is JClub's.
A single 40 IU preoperative intranasal oxytocin dose in adults undergoing traumatic fracture surgery reduced 3-day screening-positive probable acute stress disorder from 30.5% to 15.9%.
- Why it matters: Acute stress disorder is common after traumatic fracture surgery and can predict chronic posttraumatic stress disorder, yet effective drug prevention is lacking.
- What they did: In a single-center, double-blind, placebo-controlled randomized clinical trial in China (April 2024–April 2025), patients received intranasal oxytocin or saline 10 minutes before anesthesia and were assessed within 3 days using SAS-RQ (≥40).
- The result: Oxytocin showed a lower cumulative incidence (risk difference -14.6 pp; risk ratio 0.52) and a reduced adjusted hazard (0.45), with no serious adverse events observed.
The findingWhy it mattersWhat they didThe result
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