LncACTdb 4.0: an updated resource of experimentally supported ceRNA interactions and multi-level regulatory networks for precision oncology.

LncACTdb 4.0 provides 15,008 high-confidence ceRNA–disease associations and 18,974 cancer-related biomarkers, with transcriptomic profiles from >60,000 individuals and ~600,000 single cells across 69 tissues.

• Why it matters: Experimentally validated ceRNA interactions are growing, but disease-associated ceRNA networks across multi-scale biological contexts are not systematically curated for precision oncology use.
• What they did: The team built an updated repository with a four-tier architecture (tissue, cell line, organoid, single-cell) and 12 web tools for bulk-cohort, single-sample, and single-cell ceRNA analyses.
• The result: The resource enables ceRNA mechanism investigation from tissue architecture to cellular resolution and supports biomarker mining for precision oncology research.