FITdb, an integrated Functional Immunogenomics and Transcriptomics database.

FITdb integrates 43 functional genetics screens—31 bulk and 12 single-cell—covering 20 696 mouse genes and 22 293 human genes across 199 immune cell types and 29 conditions.

• Why it matters: Existing immune-cell datasets are hard to integrate because they target narrow questions, use targeted panels, vary in experimental conditions, and lack accessible harmonized resources.
• What they did: The team built FITdb, reanalyzing datasets with a standardized workflow and adding gene-centric visualizations plus single-guide RNA-level access and overlap tools.
• The result: Users can explore and compare screens via “Compare MyGeneSet” and “Compare MyScreen,” enabling statistically significant overlap detection and cross-study discovery of immune regulatory programs.