Comparative Toxicogenomics Database: update 2027.

CTD now includes over 110 million integrated toxicogenomic connections linking harmonized chemicals, genes/proteins, phenotypes, diseases, pathways, and human exposures.

• Why it matters: Environmental chemical exposures are linked to human health, but mechanistic understanding requires curated, cross-linked toxicogenomic evidence to generate testable hypotheses.
• What they did: This biennial update adds a modern web interface, a curation module capturing experimental chemical concentrations, improved CTD Tetramers with weighted evidence scoring and chord diagrams, expanded Batch Query with detailed human exposure data, and enhanced chemical identifiers for interoperability.
• The result: These enhancements strengthen CTD as a comprehensive resource for exploring molecular mechanisms and for generating testable hypotheses about chemical–disease–exposure relationships.