High ambipolar mobility fluorinated MXene for ultrasensitive biosensing transistors.

Fluorinated MXene achieves record ambipolar field-effect mobility of 10.42 and 30.23 cm² V⁻¹ s⁻¹, enabling ultrasensitive biosensing transistors.

• Why it matters: Improving MXene-based FET biosensors is crucial because current materials lack aqueous stability and have low signal transduction efficiency, limiting their practical use in bioelectronics.
• What they did: An in-situ fluorination strategy was used to synthesize high-quality fluorinated MXene, replacing oxygen terminations with fluorine, and achieving record ambipolar mobility and enhanced signal transduction.
• The result: The platform detects Mycobacterium tuberculosis antigen MPT64 with a limit of detection of 0.26 fg/ml, 97.6% accuracy across 126 serum samples, and a detection time of 38 seconds, demonstrating high performance in complex environments.