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Spatial multi-omic atlas profiles early organogenesis of a Carnegie stage 12 human embryo.
Nature Cell Biology · · Journal Article · Open access
Wang, Yang + more
Abstract ↗AI summary
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Spatial multi-omic atlas reveals distinct hepatocyte- and cholangiocyte-lineage programs and cardiac progenitors in a CS12 human embryo.
- Why it matters: Understanding the transcriptional and metabolic landscapes during early human organogenesis is limited by the lack of integrated spatial data, hindering insights into developmental mechanisms.
- What they did: Researchers generated spatial transcriptomic and metabolomic maps of a CS12 human embryo, identifying 17 cell populations and key progenitors within major organ primordia through unsupervised clustering.
- The result: The atlas uncovers spatially separable lineage-specific transcriptional and metabolic programs, providing a comprehensive framework to study early human organ development.
The findingWhy it mattersWhat they didThe result
- Open access