Metabolic homeostasis and women's reproductive health.

Dynamic, bidirectional crosstalk between metabolic organs and endocrine mediators is proposed as a central determinant of female reproductive function across the life course.

• Why it matters: Reciprocal links between metabolic homeostasis and female reproductive health have often been studied separately, leaving an incomplete systems-level framework for dysfunction and risk.
• What they did: This Review synthesizes epidemiological, mechanistic, and clinical evidence to outline an integrated model and to map disruption to conditions including polyendocrine metabolic ovarian syndrome and reproductive ageing.
• The result: The framework links network disruption to a broad range of reproductive dysfunction and cardiometabolic risk, and it evaluates metabolism-targeted strategies while proposing precision approaches for improved outcomes.

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