Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease.

Acute exercise in 25 healthy men regulates over 3,000 proteins across plasma, saliva, and urine with distinct, fluid-specific temporal dynamics.

• Why it matters: Physical activity benefits metabolic health, but the molecular mediators and their genetic links across body fluids remain incompletely mapped.
• What they did: The study built a high-resolution, time-resolved proteomics atlas from plasma, saliva, and urine after acute exercise, then used network analysis, cohort replication, and integration with genome-wide association data.
• The result: Many exercise-responsive plasma proteins show consistent responses across age, sex, and exercise modalities, and genetically prioritized muscle-specific secreted proteins validate in Drosophila for endurance, behaviour, and metabolism.

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