The abstract is read at the publisher; the summary is JClub's.
A 16-fraction hypofractionated postmastectomy radiation regimen (42.56 Gy) is noninferior to conventional PMRT (50 Gy) for reconstruction complications in women undergoing breast reconstruction.
- Why it matters: Short-course PMRT is often avoided because reconstruction complications are a concern, leaving limited evidence to guide radiation choice for patients needing reconstruction.
- What they did: In a randomized noninferiority trial (RT CHARM, Alliance A221505), 898 women with planned immediate or delayed reconstruction were assigned to 42.56 Gy/16 fractions or 50 Gy/25 fractions, with reconstruction complication rate as a composite primary endpoint.
- The result: At 24 months, reconstruction complications were 12.3% (52/422) with hypofractionated PMRT versus 10.2% (41/403) with conventional PMRT (estimated difference -2.1%, 95% CI -6.5 to 2.2), and locoregional recurrence at 36 months showed no significant difference.
The findingWhy it mattersWhat they didThe result
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