Multi-Level Toxicity of 6PPD-Q and TiO(2) Nanoparticles in Mytilus coruscus: Links among Neurochemical, Circadian and Metabolic Responses.

Combined exposure to 6PPD-Q and TiO2 nanoparticles significantly impairs Mytilus coruscus health, disrupting physiological, metabolic, and molecular functions at high concentrations.

• Why it matters: Understanding the joint effects of emerging pollutants like tire-derived chemicals and nanoparticles is crucial for assessing environmental risks to marine bivalves and aquatic ecosystems.
• What they did: The study exposed mussels to 6PPD-Q, TiO2 NPs, and their mixtures, analyzing physiological, biochemical, histological, and gene expression responses, including neurochemical and circadian regulation.
• The result: Findings reveal that co-exposure causes energy metabolism disruption, oxidative stress, and immune-apoptotic damage, highlighting potential mechanisms of pollutant-induced marine organism impairment.