Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood.

Major compositional and transcriptional changes in human peripheral blood γδ T cells occur before adulthood, with 106,711 cells analyzed across ages 1 to 90 years.

• Why it matters: Understanding age-related molecular dynamics of γδ T cells is crucial for insights into immune development and disease, yet control datasets from young healthy individuals are scarce.
• What they did: The study generated a comprehensive single-cell transcriptomic reference from 223 individuals, focusing on infancy, childhood, and adolescence, to map γδ T cell changes over the lifespan.
• The result: Findings show that the most significant shifts happen before adulthood, providing a valuable resource for future research into γδ T cell roles in health and disease.