Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Clinical Guideline From the American College of Physicians.

ACP recommends estrogen-based therapies as the most effective first-line treatment for menopausal vasomotor symptoms in females, with high-certainty evidence supporting their use.

• Why it matters: Effective management of menopausal vasomotor symptoms is essential for improving quality of life, yet optimal pharmacologic options and their comparative benefits remain unclear, necessitating evidence-based guidelines.
• What they did: The guideline reviews systematic evidence and recommends initiating estrogen with progestogen for females with a uterus or estrogen alone for those without, based on GRADE assessments, and suggests alternative treatments for contraindications or intolerance.
• The result: This guidance enables clinicians to make informed, personalized treatment decisions, balancing benefits and harms, and considering patient preferences, ultimately improving symptom management in menopausal women.