Pyridoxine can inhibit salvage of other B(6) vitamers in Salmonella enterica.

Pyridoxine inhibits salvage of other vitamin B6 vitamers in Salmonella enterica, impairing PLP acquisition and growth.

• Why it matters: Understanding how different B6 vitamers influence microbial metabolism is crucial because microbes rely on vitamin B6 for essential enzymatic functions, impacting health and environmental processes.
• What they did: The study examined Salmonella enterica growth in media with various B6 vitamers, revealing that pyridoxine can block the salvage of pyridoxamine and pyridoxal, especially in pdxH mutants, through competitive inhibition of PdxK.
• The result: This inhibition, along with PNP-mediated toxicity, hampers PLP synthesis, highlighting that B6 vitamers are not interchangeable and can distinctly affect microbial physiology and survival.