Acetyltransferase MOF Regulates Macrophage Inflammation in Abdominal Aortic Aneurysms.

MOF is increased in aortic monocyte/macrophages in human abdominal aortic aneurysms and is linked to inflammatory transcriptional programs, with TNF-α driving MOF induction.

• Why it matters: AAA formation involves an imbalance of macrophage inflammatory states, but the molecular regulators of macrophage-driven inflammation and aneurysm progression are not well defined.
• What they did: Single-cell RNA sequencing assessed MOF expression in human AAA versus control tissues, while mice used Ang II or topical porcine pancreatic elastase AAA models with myeloid-specific MOF depletion (Mof f/f Lyz2 Cre+) or MG-149 inhibition; flow cytometry and chromatin immunoprecipitation measured macrophage phenotype and H4K16ac.
• The result: In both elastase- and Ang II-induced AAA models, MOF pathway inhibition preserved macrophage function, reduced elastin fragmentation, attenuated aortic inflammation, and markedly reduced AAA development.

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