Disease modification outcomes in type 2 diabetes: a modified Delphi.

A modified Delphi process in type 2 diabetes reached consensus on a core set of 35 disease-modification outcomes across 11 domains, using two rounds with 233 and 79 participants.

• Why it matters: The field lacks a standardized outcome set for disease modification, which hampers consistent trial design and makes it difficult to compare interventions aimed at changing long-term trajectory.
• What they did: The team identified candidate outcomes from the literature, then refined them with an international multidisciplinary steering group and conducted two Delphi rounds per COMET guidance.
• The result: The resulting framework supports selecting outcomes, improving consistency across trials, enabling intervention comparisons, and evaluating disease-modifying strategies in type 2 diabetes.

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