Acute co-exposure to urban particulate matter and aircraft noise elicits lung-centered immune-redox proteomic remodeling in mice.

Acute co-exposure of male C57BL/6J mice to NIST SRM 1648a urban particulate matter plus aircraft noise elicits the broadest lung immune-redox proteomic remodeling.

• Why it matters: Particulate pollution and transportation noise co-occur, yet their combined molecular effects across organs remain poorly defined.
• What they did: Using DIA LC-MS/MS proteomics, lung, brain, and heart were profiled after 3 days of exposure to PM, NOISE, PM + NOISE, or control.
• The result: PM + NOISE most strongly induced immune and macrophage-associated proteins and linked immune signaling with NADPH oxidase and iron-handling, while brain and heart showed lower-amplitude, more selective redox and remodeling programs.

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