MCUB restricts mitochondrial calcium to support metabolic adaptation and homeostasis in glioblastoma.

MCUB restricts mitochondrial calcium flux to promote metabolic adaptation and support glioblastoma growth, with up to 80% of tumors showing increased MCUB expression.

• Why it matters: Understanding how glioblastoma maintains metabolic flexibility is crucial for developing targeted therapies, as current treatments are limited by tumor resistance and plasticity.
• What they did: The study used high-throughput screening, genetic manipulation, and in vivo models to investigate MCUB's role in regulating mitochondrial calcium and tumor response, focusing on its interaction with MCU.
• The result: Blocking MCUB-MCU interaction with TF-PPAO sensitized tumors to radiotherapy and reduced growth, suggesting MCUB as a promising therapeutic target to impair glioblastoma's metabolic resilience.