Alternate day fasting attenuates metabolic dysfunction-associated arterial thrombotic risk via increasing indole-3-propionic acid.

Alternate day fasting reduces arterial thrombotic risk in obese mice by increasing gut-derived indole-3-propionic acid (IPA) levels by 50%.

• Why it matters: Metabolic dysfunction-related arterial thrombosis is a major health issue with limited targeted therapies, highlighting the need for novel preventative strategies.
• What they did: Researchers used an obese mouse model and metabolomic analysis to investigate how ADF influences gut microbiota and identified IPA as a key metabolite mediating antithrombotic effects.
• The result: Elevated IPA levels inhibit platelet activation by maintaining Rho GTPase homeostasis, reducing thrombus formation without impairing normal clotting, and lower plasma IPA in patients predicts higher thrombotic risk.