The abstract is read at the publisher; the summary is JClub's.
Negative lumpectomy margins under 2 mm in ductal carcinoma in situ are not linked to higher ipsilateral recurrence risk in 11,156 women overall, except for age <50 years.
- Why it matters: Margin guidance for re-excision in DCIS has relied on study-level evidence, leaving uncertainty about whether patient-level margin width truly affects recurrence risk.
- What they did: In a retrospective multicenter cohort (2008–2015) from the National Cancer Database Special Study, final margin width was grouped as positive, 0.01–0.9 mm, 1.0–1.9 mm, or ≥2 mm, and ipsilateral recurrence was modeled with Kaplan-Meier and multivariable Cox regression.
- The result: Adjusted analyses showed no significant recurrence difference between negative margin groups for women receiving BCS with radiotherapy or BCS alone, while subgroup testing found a significant narrow-versus-wide margin effect only in patients younger than 50 years.
The findingWhy it mattersWhat they didThe result
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