Whole-grain consumption and cardiometabolic risk: a meta-analysis of randomized trials.

A 48 g/day increment in whole-grain intake in randomized trials is linked to lower body weight by a mean difference of -0.20 kg (95% CI -0.31 to -0.09; n=41).

• Why it matters: Although higher whole-grain intake is associated with reduced cardiometabolic disease risk, the specific risk-factor changes and their dose patterns are not well established.
• What they did: Eighty-seven randomized trials (101 publications) were pooled using random-effects meta-analysis to estimate mean differences per 48 g/day increment of whole grains (dry weight).
• The result: Whole-grain intake also reduced several cardiometabolic markers, with the strongest effects generally appearing at 60–100 g/day for most outcomes, while higher intakes had limited data.

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