Fucosylated hemocyanin regulates ER stress to enhance shrimp antibacterial immunity.

Fucosylated hemocyanin enhances shrimp antibacterial immunity by regulating ER stress and AMP production, reducing Vibrio parahaemolyticus loads by 50%.

• Why it matters: Understanding how post-translational modifications like fucosylation influence immune signaling in crustaceans fills a critical gap in invertebrate immunology and could improve disease management.
• What they did: The study used biotin pull-down, LC-MS/MS, and functional assays to show that highly fucosylated Pv HMC interacts with ER chaperone Pv Bip, activating ER stress pathways and increasing antimicrobial peptide transcription in shrimp.
• The result: High-fucosylated Pv HMC significantly decreased Vibrio loads and increased shrimp survival, revealing a novel intracellular immune mechanism that could inform strategies to enhance crustacean disease resistance.