Development of a functional and disinfectable sewage vent high-efficiency particulate air filter system and its validation using vaporized hydrogen peroxide.

A vaporized hydrogen peroxide (vH2O2) disinfection cycle with high humidity achieves ≥4 log 10 reduction of spores and viruses in biological containment settings.

• Why it matters: Effective disinfection of sewage vent air in high-containment facilities is critical to prevent pathogen spread, yet it is often overlooked in HEPA filter system design, risking safety.
• What they did: The study developed a biphasic vH2O2 disinfection protocol, monitored temperature, humidity, and vH2O2 levels, and validated it using carrier testing with spores and viruses, targeting ≥4 log 10 reduction.
• The result: High-to-saturated humidity combined with medium-high vH2O2 concentrations effectively inactivates resistant agents like murine norovirus and G. stearothermophilus spores, enabling safe infrastructure disinfection.