Immunogenicity evaluation of recombinant rabies virus-vectored multivalent vaccines expressing feline calicivirus VP1 and feline herpesvirus 1 gB/gD genes.
Recombinant rabies virus-vectored vaccines induce strong immune responses and protection against feline calicivirus, feline herpesvirus 1, and rabies virus in mice and cats.
- Why it matters: Feline calicivirus and feline herpesvirus 1 are major threats to feline health, and effective multivalent vaccines are needed to improve prevention strategies.
- What they did: Two recombinant rabies virus vaccines expressing FCV VP1 and FHV-1 gB/gD genes were constructed, tested for stability, immunogenicity, and protective efficacy in mice and cats, with 3 pathogens targeted.
- The result: The vaccines elicited specific and neutralizing antibodies, reduced clinical signs, and provided protection against viral challenges, supporting their potential as safe, multivalent feline vaccines.