The abstract is read at the publisher; the summary is JClub's.
4-MBC exposure in zebrafish causes concentration-dependent developmental neurotoxicity, including developmental malformations, reduced hatching rates, and suppressed larval locomotion at 1–1000 μg/L.
- Why it matters: Mechanisms linking 4-MBC’s environmental and tissue accumulation to developmental neurotoxicity are unclear, limiting reliable risk assessment.
- What they did: Network toxicology predicted 150 targets and 10 core targets, while docking/dynamics suggested stable binding to core proteins; zebrafish transcriptomics found 311 dose-responsive genes and RT-qPCR confirmed gene shifts at 100 and 1000 μg/L.
- The result: The integrated model implicates disrupted glutamatergic synapses, dysregulated MAPK signaling, and defective DNA replication, with AOP analysis pointing to impaired DNA repair as a converged node.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.