Takotsubo syndrome diagnosis: the biomarker-based BioTAK score.

BioTAK, a five-biomarker diagnostic score plus sex, discriminates Takotsubo syndrome from acute coronary syndrome with AUC 0.97 in a development cohort.

• Why it matters: Early differentiation of Takotsubo syndrome from acute coronary syndrome before invasive coronary angiography is difficult because current diagnosis depends on history, repeated imaging, and exclusion of culprit lesions.
• What they did: In 3615 ACS or TTS patients from overlapping registries, circulating biomarkers were measured before ICA; BioTAK was built in 1823 patients using machine-learning feature selection and logistic regression, then externally validated in 1792.
• The result: BioTAK achieved AUC 0.93 on external validation with good calibration and, using predefined thresholds, stratified almost 90% of patients to a likely diagnosis prior to ICA.

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