Data-driven optimization of siderophore fermentation by Bacillus altitudinis AS19 and investigation of AS19's antifungal properties against Candida albicans.
- Open access
Optimized fermentation of Bacillus altitudinis AS19 increased siderophore yield over twofold, enhancing its antifungal activity against Candida albicans.
- Why it matters: The rise of antifungal resistance in Candida albicans demands new treatment strategies; natural siderophores offer promising alternatives with targeted antimicrobial effects.
- What they did: Using response surface methodology and an artificial neural network-genetic algorithm, researchers optimized culture conditions for siderophore production, and employed molecular docking, LC-MS, and in vitro assays to investigate its antifungal mechanism.
- The result: The study confirmed potent antifungal activity of the siderophore extract, identified key compounds like Nocardamin Glucuronide, and laid a foundation for developing novel siderophore-based antifungal agents.