Heterodera filipjevi Effector Hf70514 Targets TaCYPA-1 Protein to Suppress Immunity and Enhance Susceptibility in Wheat.

Hf70514 from Heterodera filipjevi targets wheat TaCYPA-1 and suppresses plant immunity, with TaCYPA-1 silencing significantly enhancing parasitism.

• Why it matters: The effector repertoire and how H. filipjevi suppresses wheat defenses during infection remain poorly resolved, limiting targeted control strategies.
• What they did: Stage-resolved transcriptomics prioritized secreted candidates, and expression/localization were validated; in vitro and in planta RNAi tested virulence roles, while ROS burst assays and protein-protein interaction identified TaCYPA-1 as a target of Hf70514.
• The result: Hf70514 suppressed flg22-induced ROS, and transient silencing of TaCYPA-1 enhanced H. filipjevi parasitism with down-regulation of defense-related genes.

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