Tutorial: strategies for targeting organelles using nanoparticles.

Nanoparticles can be rationally designed to control intracellular trafficking and localization to specific organelles, enabling precise diagnostics and therapies across multiple disease contexts.

• Why it matters: Organelle dysfunction is implicated in many critical diseases, but achieving precise subcellular delivery is challenging. Targeted nanomedicine aims to close this gap for diagnostics and treatment.
• What they did: This Tutorial reviews design strategies for nanoparticles aimed at mitochondria, lysosomes, the nucleus, the endoplasmic reticulum, and the Golgi apparatus. It also outlines core principles and experimental methods to validate subcellular localization.
• The result: The guide provides a systematic, actionable framework for developing next-generation organelle-targeted nanomedicines for both fundamental research and translational applications. It also highlights emerging frontiers in the field.

AI summary of the abstract · may contain errors · not medical advice · read the paper.