Prefrontal gamma oscillations engage dynamic cell-type-specific configurations to support flexible behavior.

PVIs in mice dynamically synchronize with MD-projecting PFC neurons to generate multiple distinct, distributed gamma synchronization patterns (∼40 Hz) recruited for specific flexible behaviors.

• Why it matters: Disrupted PFC–MD communication and deficient PVI-driven gamma oscillations are linked to cognitive dysfunction, but how gamma patterns regulate this pathway and flexibility is unclear.
• What they did: Using dual-color voltage indicators and optogenetics in mice, the study measured local and contralateral PVI synchrony with MD-projecting PFC neurons and identified distinct circuit-specific gamma synchronization motifs.
• The result: Gamma oscillations are linked to diverse cell-type-specific motifs with particular phase relationships, which are dynamically recruited to support particular components of flexible behavior in mice.

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