Nonexhaustive microextraction as a step toward more sustainable chemical analysis in the field and the clinic.

Nonexhaustive solid-phase microextraction enables integrated sampling, extraction, cleanup, and enrichment with high analytical efficiency while minimizing solvent use.

• Why it matters: Conventional exhaustive sample preparation is a bottleneck because it is laborious, solvent-intensive, and time-consuming, limiting sustainable field and clinical chemical analysis.
• What they did: The approach uses nonexhaustive partitioning enrichment via sorbent-coated objects, optimized for targeted analytes, sample matrix, and downstream detection, and can be coupled to GC-MS, LC-MS, or sensors.
• The result: Integrating microextraction into automated workflows supports a conceptual framework for more unified, adaptive, and environmentally responsible sample preparation methods.

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