The abstract is read at the publisher; the summary is JClub's.
Discontinuing renin-angiotensin system inhibitors before non-cardiac, non-vascular surgery is linked to less peri-operative hypotension (27.66% vs 34.06%; RR 0.81).
- Why it matters: The optimal pre-surgery strategy is unclear because continuation may raise hypotension risk, while stopping may increase hypertension and heart-failure risk.
- What they did: A systematic review and meta-analysis of randomized controlled trials compared discontinuation versus continuation in 10,773 patients undergoing non-cardiac, non-vascular surgery.
- The result: Discontinuation likely reduces peri-operative hypotension, while effects on peri-operative hypertension and major outcomes (acute kidney injury, heart failure, myocardial infarction, stroke, arrhythmias) are very uncertain or show little to no difference.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.