The abstract is read at the publisher; the summary is JClub's.
Microglial Stim1/Stim2 deletion in 15-month-old mice reduces CRAC-mediated calcium transients by one-third but worsens ischemic stroke outcome in males, with infarct expansion up to 2.7-fold.
- Why it matters: CRAC calcium signaling in microglia is linked to pro-inflammatory immune responses, but its net effect on threatened brain tissue after ischemia is unclear.
- What they did: Using Cx3cr1-CreERT2; Stim cKO mice, in vivo two-photon imaging quantified calcium transients during cortical spreading depolarizations, then distal middle cerebral artery occlusion was followed by multiparametric MRI at 9.4 T.
- The result: At 6 hours infarct size and edema were similar, but from 6–48 hours control male infarcts did not grow while cKO males expanded 2.7-fold and at 48 hours were 2.2-fold larger with lower apparent diffusion coefficient.
The findingWhy it mattersWhat they didThe result
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