The abstract is read at the publisher; the summary is JClub's.
Older adults (52–75 years) with comparable BMI show markedly higher senescence-associated marker expression in human omental visceral adipose, including CDKN2A (p16INK4a) and CDKN1A (p21CIP1).
- Why it matters: Obesity is linked to aging hallmarks, but how cellular senescence changes with age when adiposity is held similar is unclear, limiting understanding of VAT dysfunction and inflammation.
- What they did: Using cross-sectional human omental VAT (18–35, 36–51, 52–75 years; BMI 40 {+/-}5 kg/m2), the study integrated bulk and single-nucleus RNA-seq, Visium HD spatial transcriptomics, and three computational senescent-cell identification methods.
- The result: Senescent cells increased non-linearly with age, concentrated in adipose stem/progenitor cells and mesothelium, and CellChat predicted shared outgoing inflammatory and remodeling signaling (IL-1, IL-6, TGF-{beta}, WNT) that aligns with transcriptional programs in SnCs.
The findingWhy it mattersWhat they didThe result
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