The abstract is read at the publisher; the summary is JClub's.
T1-weighted white matter hypointensity volume (T1-WMHypo) shows lifespan normative trajectories in 34,148 healthy individuals aged 4–85 years, enabling deviation-based disease profiling.
- Why it matters: T1-WMHypo is a proposed marker of white matter pathology but has been less systematically characterized than T2-FLAIR lesions, limiting clinical interpretation across disorders.
- What they did: The study built a lifespan reference for T1-WMHypo volume from 34,148 healthy participants, then compared it with 7,587 patients across 21 neurological and psychiatric disorders to quantify deviations.
- The result: Deviations were disease-specific, linked to brain atrophy, cognitive impairment, and poorer outcomes, predicted poor medication response in Parkinson’s disease and faster disability progression in multiple sclerosis, and remained significant after adjusting for T2-FLAIR hyperintensity lesions.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.