The abstract is read at the publisher; the summary is JClub's.
Hemisphere-dependent longitudinal changes in frontoparietal–subgenual anterior cingulate cortex joint temporal complexity (bMSE-CI) differ between accelerated TMS patients and healthy controls, with a significant Group × Time × Hemisphere interaction (F(1,37)=6.043, p=0.0188).
- Why it matters: Depression research needs biomarkers that capture how brain dynamics evolve over time, and it is unclear whether FP–sgACC coupling complexity changes differently by hemisphere during treatment versus no treatment.
- What they did: Twenty-four patients with current depressive episodes and fifteen healthy controls completed 7T resting-state fMRI at baseline and follow-up; patients received accelerated TMS to left DLPFC, and bivariate multiscale sample entropy was computed for bilateral FP paired separately with left versus right sgACC.
- The result: Only scale factor a2 showed a significant Group × Time × Hemisphere interaction after FDR correction (q=0.0435), and no bMSE–MADRS baseline or change associations survived correction; exploratory findings support bMSE as a candidate longitudinal neural-change measure.
The findingWhy it mattersWhat they didThe result
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