The abstract is read at the publisher; the summary is JClub's.
In Clostridium tyrobutyricum ATCC 25755, xylose utilization shows CCR-like inhibition with 2-DG, yet xylose-rich mixtures still support high butyric acid productivity (1.22 g/L/h).
- Why it matters: CCR can limit xylose use from lignocellulosic hydrolysates, reducing butyric acid yields when glucose is also present.
- What they did: The study tested 2-deoxy-D-glucose (2-DG) effects on growth in xylose-containing medium and ran batch fermentations with 80 g/L total sugars across glucose–xylose compositions, plus co-utilization assays and rice straw hydrolysate fermentation.
- The result: 2-DG inhibited growth concentration-dependently and reduced xylose consumption rate from 2.68 to 0.53 g/L/h as glucose rose from 20 to 60 g/L, but xylose-rich mixtures (20 g/L glucose, 60 g/L xylose) achieved 3.54 g/L/h total sugar consumption and 1.22 g/L/h butyric acid productivity, with detectable xylose isomerase activity and complete sugar consumption in rice straw hydrolysate producing 7.68 g/L butyric acid.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.