The abstract is read at the publisher; the summary is JClub's.
In 978 residual NG-negative specimens from two England sexual health services, Xpert(R) CT/NG correctly confirmed 99.7% as negative, with 3 GeneProofTM positives showing single-target amplification only.
- Why it matters: UKHSA confirmed a Neisseria gonorrhoeae Xpert(R) CT/NG diagnostic escape mutant, raising concern that near-patient testing could miss some true NG cases.
- What they did: During December 2025, NG-negative specimens were tested on GeneProofTM PCR, GeneProofTM NG-positive samples were re-tested on Xpert(R) CT/NG, and Xpert(R) target behavior (NG2 vs NG4) was assessed.
- The result: Two re-tested samples were NG-negative on Xpert(R) CT/NG despite amplifying either NG2 or NG4 alone, and extrapolation suggests 62–562 missed NG cases in 2025 from these clinics.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.