The abstract is read at the publisher; the summary is JClub's.
Hospitalisation for pneumonia in 12–36-month-old children in Blantyre, Malawi is expected to generate a persistent hospital-acquired nasopharyngeal resistome pattern, linked to 3-month re-hospitalisation risk.
- Why it matters: AMR to first-line pneumonia antibiotics is a major sub-Saharan Africa problem, yet it is unclear how children’s nasopharyngeal resistomes change with antibiotic and healthcare exposure and relate to outcomes.
- What they did: This observational case-control protocol recruits 350 children across four groups and uses nasopharyngeal metagenomic sequencing at recruitment and 3-month follow-up, plus urine antibiotic activity bioassays.
- The result: The study is powered for a medium effect (Cohens D = 0.505) in relative ARG abundance, testing primary outcomes as beta diversity (Bray-Curtis dissimilarity) and ARG class abundance differences, including persistence in re-hospitalised participants.
The findingWhy it mattersWhat they didThe result
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