The abstract is read at the publisher; the summary is JClub's.
A jump-diffusion model of single-cohesin dynamics shows that finite stall force emerges from active directional extrusion combined with passive stochastic drift under tension.
- Why it matters: Existing biophysical models cannot efficiently capture the range of cohesin behaviors reported across conditions, nor link them to DNA spatio-temporal organization and CTCF barrier effects.
- What they did: Using a mesoscale jump-diffusion framework parametrized from single-molecule measurements, the model predicts tension-dependent competition between orthogonal motion modes and identifies extrusion, translocation, and loop slipping phases.
- The result: The model matches force-dependent extrusion in DNA curtain assays in vitro and supports genome folding predictions in nucleo, explaining how CTCF impedes extrusion while buffer composition and nucleosomal content tune heterogeneous kinetics.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.