Haploidy-linked disruption of tissue organization in zebrafish larval eyes

Haploid zebrafish larval eyes show disorganized retinal tissue layers, with reduced and severely displaced photoreceptors and abnormal ganglion-cell organization.

• Why it matters: Somatic haploidy is known to cause lethality and major morphology changes, but its cellular and tissue-level impacts on organ development are not well defined.
• What they did: Using zebrafish larval eyes as a tissue model, the study compared haploid versus normal retinas to assess photoreceptor and ganglion-cell number, positioning, and photoreceptor cilia/outer-segment development.
• The result: Haploid retinas exhibit severe visual-functional defects, including drastic retardation of photoreceptor connecting cilia and outer segments, beyond previously recognized size reductions.

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