Cell wall composition drives off-target sensitivity to indaziflam

Indaziflam shows strong, dose-dependent off-target sensitivity only in the bryophyte Marchantia polymorpha, with thallus surface area suppressed above 1600 pM.

• Why it matters: The ecological risk of indaziflam beyond weeds is unclear, especially for organisms with non-cellulose cell wall architectures that may be expected to respond differently.
• What they did: Growth and biomass impacts were tested across Saccharomyces cerevisiae, Chlamydomonas reinhardtii, and Marchantia polymorpha, including in vitro thallus measurements and greenhouse pre-emergence applications at 1X–3X field rates.
• The result: Marchantia polymorpha exhibited significant suppression (p<0.05) and greenhouse treatment achieved up to 100% control of liverwort establishment and biomass over 8 weeks, while yeast and alga showed no growth suppression.

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