The abstract is read at the publisher; the summary is JClub's.
CLP sepsis in mice increases myeloid Scavenger Receptor A (CD204) expression on neutrophils and monocytes/macrophages, whereas SR-A expression is unchanged in leukocytes from septic patients.
- Why it matters: The study addresses a gap in understanding how SR-A regulation during sepsis differs across species and whether it contributes to human disease severity.
- What they did: Mouse leukocytes were analyzed after cecal ligation and puncture, and patient leukocytes were analyzed from sepsis cases; flow cytometry measured SR-A on neutrophils and monocytes/macrophages, with PAMP stimulation in isolated myeloid cells.
- The result: In mice, Pam3CSK4 and LPS increased SR-A expression, and C. albicans glucan increased SR-A on human monocytes; in patients, SR-A did not change and did not correlate with SOFA II scores.
The findingWhy it mattersWhat they didThe result
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