The abstract is read at the publisher; the summary is JClub's.
N332-GT6 gp151 mRNA-LNP vaccination in nonhuman primates primes BG18-class bnAb precursor B cells more consistently after one immunization than N332-GT5.
- Why it matters: Prophylactic HIV vaccines must overcome the challenge of priming ultrarare bnAb precursors from the naive B cell pool.
- What they did: Across three NHP studies, membrane-bound gp151 trimers encoding N332-GT5 or N332-GT6 were delivered as mRNA-LNP vaccines, with N332-GT6 engineered for a 9-fold higher affinity to diverse BG18-class precursor naive B cells.
- The result: Two heterologous mRNA-LNP boosters drove affinity maturation and generated BG18-class memory B cells that bind wildtype HIV Env, showing mRNA can support GT priming, boosting, and early maturation in NHPs.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.