The abstract is read at the publisher; the summary is JClub's.
Sustained versus transient SOX9 expression in axolotl limb mesenchyme fate mapping predicts distinct outcomes: Sox9-retaining cells contribute little to skeletal regeneration, while Sox9-downregulating cells extensively regenerate cartilage.
- Why it matters: Cell fate transcription factor dynamics are unclear during how limb identities emerge in development and are rebuilt during regeneration.
- What they did: The study genetically fate-mapped Sox9-expressing cells in axolotl limb development and tracked their fates, then compared their roles during early limb regeneration, including whether Sox9 reinitiates.
- The result: Sox9-retaining cells become cartilage or perichondrial cells, whereas Sox9-downregulating cells become dermal or interstitial fibroblasts and can reinitiate Sox9 to form new cartilage, with transient Sox9 expression also seen early in regeneration.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.