The extended default mode network dysconnectivity in schizophrenia

In resting-state fMRI, the extended default mode network’s causal centrality is preserved in schizophrenia, with highly similar regional rankings (ρ = 0.87) across 66 SZ patients and 74 healthy controls.

• Why it matters: The extended DMN reaches subcortical areas, but it is unclear how its causal organization is reorganized in schizophrenia and whether such changes relate to cognition.
• What they did: The study used spatially constrained independent component analysis to define subject-specific eDMNs, then estimated effective connectivity among 13 regions with spectral dynamic causal modeling and computed causal centrality per region.
• The result: Temporal cortex causal centrality was higher in patients and posterior parietal cortex higher in controls; temporal centrality correlated negatively with reasoning/problem-solving, and ventrolateral prefrontal centrality correlated with processing speed and composite cognition.

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