Craniofacial abnormalities from TNAP and PHOSPHO1 deletion highlight their dual role in bone and tooth mineralisation

Dual loss of Alpl and Phospho1 in Prx1-Cre mice exacerbates craniofacial and dental mineralisation defects, further reducing dentin volume and thickness beyond Phospho1 deletion alone.

• Why it matters: TNAP and PHOSPHO1 are known cooperative regulators of postnatal skeletal mineralisation, but how they interact during craniofacial development and dentoalveolar mineralisation remains unclear.
• What they did: The study used Prx1-mediated Alpl deletion on a global Phospho1-null background in mice, comparing craniofacial morphology and dentin volume/thickness across single and dual deletions.
• The result: Phospho1 deletion caused craniofacial hypoplasia with frontonasal hypoplasia, reduced cranial vault height, and mandibular micrognathia, and dual deletion further decreased dentin volume and thickness, supporting a synergistic role in permissive biomineralisation.

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