Proton pump inhibitor-associated microbiomes shape systemic host responses

PPI-associated gut microbiome remodeling transfers to germ-free mice and reproduces human-linked shifts in aromatic amino acid metabolism, with added systemic lipid changes.

• Why it matters: Although PPIs alter the gut microbiome, how those microbial shifts relate to systemic metabolic and inflammatory effects is unclear.
• What they did: They integrated human microbiome and metabolomics with metabolic modelling to find altered microbial functions and host–microbiome co-metabolism, then transferred PPI-associated microbiota into germ-free mice.
• The result: The transferred microbiota triggered tissue-specific transcriptional responses in colon, liver, and brain, implicating metabolic and inflammatory pathways and yielding transferable systemic signatures linked to PPI use.

AI summary of the abstract · may contain errors · not medical advice · read the paper.