The abstract is read at the publisher; the summary is JClub's.
Patient-derived Ewing sarcoma cells in an in vivo zebrafish model show organotropism with correlated organ targeting, revealing recurrent spatial preferences across the fish body.
- Why it matters: Metastasis requires navigating organ-specific barriers, but existing tools struggle to track dissemination at whole-organism scale while staying physiologically relevant.
- What they did: The study combines an in vivo zebrafish dissemination model with a data-driven computational framework that uses global heterogeneity plus local metrics for region-specific colonization frequency and cancer cell visit density.
- The result: The global-local analysis uncovers coordinated, structured metastatic patterns that depend on cancer cell line and disease stage, and the framework scales to varied imaging datasets and perturbations.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.